Evaluation of the renal clearance of technetium-99m PAHIDA in dogs

J Nucl Med. 1987 May;28(5):907-9.

Abstract

The renal clearance of the technetium-99m complex of para[(biscarboxylmethyl)-aminomethylcarboxyamino]hippuric acid ([99mTc]PAHIDA), has been previously studied in rodents and falls between that of [99mTc]DTPA (diethylenetriaminepentaacetic acid) and iodine-131 (131I) orthoiodohippuran (OIH). To investigate the effect of species variation, the plasma clearance of [99mTc]PAHIDA was investigated in dogs. The plasma disappearance of the renal agent approached that of [99mTc]DTPA and was significantly less than that of OIH. Despite the structural similarities of the PAHIDA ligand and aminohippurate, the [99mTc]PAHIDA complex undergoes little, if any, tubular secretion in the canine kidney.

Publication types

  • Comparative Study

MeSH terms

  • Aminohippuric Acids / metabolism*
  • Animals
  • Dogs
  • Iodohippuric Acid / metabolism
  • Kidney / metabolism*
  • Organometallic Compounds / metabolism
  • Pentetic Acid / metabolism
  • Technetium / metabolism
  • Technetium Tc 99m Pentetate
  • p-Aminohippuric Acid / metabolism*

Substances

  • Aminohippuric Acids
  • Organometallic Compounds
  • Iodohippuric Acid
  • Technetium
  • Pentetic Acid
  • 4-((bis(carboxymethyl)aminomethyl)carbamino)hippuric acid
  • Technetium Tc 99m Pentetate
  • p-Aminohippuric Acid