Abstract
We compared the internalization of [90Y-DOTA0,Tyr3]octreotide and [111In-DOTA0,Tyr3]octreotide with that of [125I-Tyr3]octreotide and [111In-DTPA0]octreotide in the subtype 2 somatostatin receptor (sst2)-positive rat pancreatic tumour cell lines CA20948 and AR42J and in the somatostatin receptor-negative human anaplastic thyroid tumour cell line ARO. We demonstrated that [111In-DTPA0]octreotide, [90Y-DOTA0,Tyr3]octreotide and [111In-DOTA0,Tyr3]octreotide are internalized by a receptor-specific, time- and temperature-dependent process. The amount of [90Y-DOTA0,Tyr3]octreotide internalized was higher than that of [111In-DOTA0,Tyr3]octreotide and [111In-DTPA0]octreotide.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding, Competitive
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Biological Transport
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Carcinoma / metabolism
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Cell Line
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Humans
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Indium Radioisotopes / pharmacokinetics
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Kinetics
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Octreotide / analogs & derivatives
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Octreotide / pharmacokinetics*
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Pancreatic Neoplasms / metabolism*
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Pentetic Acid / analogs & derivatives
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Pentetic Acid / pharmacokinetics*
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Radiopharmaceuticals / pharmacokinetics*
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Rats
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Receptors, Somatostatin / metabolism*
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Temperature
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Thyroid Neoplasms / metabolism*
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Tumor Cells, Cultured
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Yttrium Radioisotopes / pharmacokinetics
Substances
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Indium Radioisotopes
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Radiopharmaceuticals
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Receptors, Somatostatin
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Yttrium Radioisotopes
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Pentetic Acid
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Octreotide