Abstract
The accumulation of three 99mTc(I) alkyl isonitriles was compared in vitro and in vivo using 9L gliosarcoma cells. In vitro, the uptake of 99mTc-EIBI and 99mTc-EPI was higher than that of 99mTc-MIBI. In vivo, however, there was no difference in the tumor concentration at 15 or 60 min postinjection and only a small difference at 24 h. The differences in uptake observed in vitro are apparently offset in vivo by differences in delivery of the tracers to the tumor.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain Neoplasms / diagnostic imaging
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Brain Neoplasms / metabolism*
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Gliosarcoma / diagnostic imaging
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Gliosarcoma / metabolism*
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Male
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Nitriles / pharmacokinetics*
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Organotechnetium Compounds / pharmacokinetics*
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Radionuclide Imaging
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Rats
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Technetium Tc 99m Sestamibi / pharmacokinetics*
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Tissue Distribution
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Tumor Cells, Cultured
Substances
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Nitriles
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Organotechnetium Compounds
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technetium Tc 99m ethoxypropylisonitrile
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technetium Tc 99m ethoxyisobutylisonitrile
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Technetium Tc 99m Sestamibi