Characterization of [3H]GR 113808 binding to 5-HT4 receptors in brain tissues from patients with neurodegenerative disorders

Behav Brain Res. 1996;73(1-2):249-52. doi: 10.1016/0166-4328(96)00106-4.

Abstract

[3H]GR 113808 binding studies in guinea-pig brain tissue revealed a temperature dependency and pharmacological specificity consistent with labelling of a 5-HT4 receptor. Detailed comparison of competition data between brain regions from human and guinea-pig suggest minor differences in the rank order of affinity. Studies in brain tissue from patients with Alzheimer's Huntington's and Parkinson's disease have revealed specific deficits in 5-HT4 receptor densities.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / metabolism
  • Animals
  • Binding, Competitive / drug effects
  • Brain / metabolism*
  • Female
  • Guinea Pigs
  • Humans
  • Huntington Disease / metabolism
  • In Vitro Techniques
  • Indoles / pharmacokinetics*
  • Male
  • Middle Aged
  • Nerve Degeneration
  • Nervous System Diseases / metabolism*
  • Parkinson Disease / metabolism
  • Receptors, Serotonin / metabolism*
  • Serotonin Antagonists / pharmacokinetics*
  • Sulfonamides / pharmacokinetics*

Substances

  • Indoles
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Sulfonamides
  • GR 113808