Abstract
[3H]GR 113808 binding studies in guinea-pig brain tissue revealed a temperature dependency and pharmacological specificity consistent with labelling of a 5-HT4 receptor. Detailed comparison of competition data between brain regions from human and guinea-pig suggest minor differences in the rank order of affinity. Studies in brain tissue from patients with Alzheimer's Huntington's and Parkinson's disease have revealed specific deficits in 5-HT4 receptor densities.
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / metabolism
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Animals
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Binding, Competitive / drug effects
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Brain / metabolism*
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Female
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Guinea Pigs
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Humans
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Huntington Disease / metabolism
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In Vitro Techniques
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Indoles / pharmacokinetics*
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Male
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Middle Aged
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Nerve Degeneration
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Nervous System Diseases / metabolism*
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Parkinson Disease / metabolism
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Receptors, Serotonin / metabolism*
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Serotonin Antagonists / pharmacokinetics*
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Sulfonamides / pharmacokinetics*
Substances
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Indoles
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Receptors, Serotonin
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Serotonin Antagonists
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Sulfonamides
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GR 113808