Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model

M R Horsman; A A Khalil; M Nordsmark; C Grau; J Overgaard

doi:10.1016/0167-8140(93)90188-e

Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model

Radiother Oncol. 1993 Jul;28(1):69-71. doi: 10.1016/0167-8140(93)90188-e.

Authors

M R Horsman¹, A A Khalil, M Nordsmark, C Grau, J Overgaard

Affiliation

¹ Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus.

PMID: 8234872
DOI: 10.1016/0167-8140(93)90188-e

Abstract

CDF1 mice were allowed to breathe either oxygen, carbogen or different concentrations of carbon monoxide gas. These treatments significantly altered the percentage of clonogenic hypoxic cells in a C3H mouse mammary carcinoma and these changes were found to correlate with direct measurements of tumour oxygenation obtained using an Eppendorf pO2 electrode.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carbon Dioxide / administration & dosage
Cell Hypoxia
Female
Male
Mammary Neoplasms, Experimental / metabolism*
Mammary Neoplasms, Experimental / radiotherapy*
Mice
Mice, Inbred Strains
Oxygen / metabolism*
Respiration

Substances

Carbon Dioxide
Oxygen