Prevention of renal tubule re-absorption of radiometal (indium-111) labelled Fab fragment of a monoclonal antibody in mice by systemic administration of lysine

M V Pimm; S J Gribben

doi:10.1007/BF00285590

Prevention of renal tubule re-absorption of radiometal (indium-111) labelled Fab fragment of a monoclonal antibody in mice by systemic administration of lysine

Eur J Nucl Med. 1994 Jul;21(7):663-5. doi: 10.1007/BF00285590.

Authors

M V Pimm¹, S J Gribben

Affiliation

¹ Cancer Research Laboratories, University of Nottingham, UK.

PMID: 7957354
DOI: 10.1007/BF00285590

Abstract

Systemic administration of lysine to mice injected with indium-111-labelled Fab fragment of a monoclonal antibody has been shown to reduce renal uptake/retention of the radiometal. This treatment should be applicable to clinical immunoscintigraphy and radioimmunotherapy with radiometal-labelled antibody fragments.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Immunoglobulin Fab Fragments
Indium Radioisotopes*
Kidney Tubules / diagnostic imaging*
Lysine / therapeutic use*
Mice
Mice, Inbred BALB C
Radioimmunodetection*
Radioimmunotherapy
Tissue Distribution

Substances

Immunoglobulin Fab Fragments
Indium Radioisotopes
Lysine