Abstract
Systemic administration of lysine to mice injected with indium-111-labelled Fab fragment of a monoclonal antibody has been shown to reduce renal uptake/retention of the radiometal. This treatment should be applicable to clinical immunoscintigraphy and radioimmunotherapy with radiometal-labelled antibody fragments.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Immunoglobulin Fab Fragments
-
Indium Radioisotopes*
-
Kidney Tubules / diagnostic imaging*
-
Lysine / therapeutic use*
-
Mice
-
Mice, Inbred BALB C
-
Radioimmunodetection*
-
Radioimmunotherapy
-
Tissue Distribution
Substances
-
Immunoglobulin Fab Fragments
-
Indium Radioisotopes
-
Lysine