Abstract
Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Breast Neoplasms / enzymology*
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Breast Neoplasms / pathology
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Carcinoma in Situ / enzymology*
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Carcinoma in Situ / pathology
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Carcinoma in Situ / secondary
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Carcinoma, Ductal, Breast / enzymology*
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Carcinoma, Ductal, Breast / pathology
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Carcinoma, Ductal, Breast / secondary
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ErbB Receptors / analysis
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ErbB Receptors / genetics
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Evaluation Studies as Topic
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Female
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Follow-Up Studies
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Gene Expression / genetics
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Glutathione Transferase / analysis*
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Humans
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Immunohistochemistry
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Isoenzymes / analysis*
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Middle Aged
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Proto-Oncogene Proteins / analysis
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Proto-Oncogene Proteins / genetics
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Receptor, ErbB-2
Substances
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Isoenzymes
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Proto-Oncogene Proteins
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Glutathione Transferase
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ErbB Receptors
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Receptor, ErbB-2