Abstract
[11C]Methyl triflate was compared with [11C]methyl iodide as a labelled precursor in the synthesis of some commonly used PET radioligands, L-[11C]deprenyl, [11C]m-hydroxyephedrine (MHED), [11C] beta-CIT, [11C] beta-CFT and [11C]SCH 39166 which have been prepared previously in comparatively low yields from [11C]methyl iodide. A new dopamine reuptake radioligand, [11C] alpha-CIT, was also prepared. The results demonstrate that higher yields are obtained with shorter reaction times, lower reaction temperatures and smaller amounts of precursors with [11C]methyl triflate.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Benzazepines / chemical synthesis*
-
Carbon Radioisotopes*
-
Chromatography, High Pressure Liquid
-
Cocaine / analogs & derivatives
-
Cocaine / chemical synthesis
-
Dopamine Antagonists / chemical synthesis
-
Ephedrine / analogs & derivatives*
-
Ephedrine / chemical synthesis
-
Hydrocarbons, Iodinated
-
Indicators and Reagents
-
Isotope Labeling / methods
-
Magnetic Resonance Spectroscopy
-
Mesylates*
-
Radioligand Assay
-
Selegiline / chemical synthesis*
-
Tomography, Emission-Computed / methods*
Substances
-
Benzazepines
-
Carbon Radioisotopes
-
Dopamine Antagonists
-
Hydrocarbons, Iodinated
-
Indicators and Reagents
-
Mesylates
-
ecopipam
-
Selegiline
-
3-hydroxyephedrine
-
methyl triflate
-
2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
-
methyl iodide
-
Ephedrine
-
Cocaine