Concentrations of serotonin and its related substances in the cerebrospinal fluid of parkinsonian patients and their relations to the severity of symptoms

Neurosci Lett. 1993 Feb 5;150(1):71-4. doi: 10.1016/0304-3940(93)90111-w.

Abstract

We evaluated the concentrations of free and total serotonin (5-hydroxytryptamine, 5-HT) and its related substances in the cerebrospinal fluid from patients with Parkinson's disease (PD). The concentrations of total 5-HT, 5-hydroxytryptophan, kynurenine and 3-hydroxykynurenine decreased significantly in PD patients compared with controls. The concentration of total 5-HT had significant negative correlations with Hoehn and Yahr's stages, the severity of rigidity, akinesia and gait freezing; the correlation with gait freezing was most conspicuous.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5-Hydroxytryptophan / cerebrospinal fluid
  • Humans
  • Hydroxyindoleacetic Acid / cerebrospinal fluid
  • Kynurenine / analogs & derivatives
  • Kynurenine / cerebrospinal fluid
  • Middle Aged
  • Parkinson Disease / cerebrospinal fluid*
  • Parkinson Disease / physiopathology*
  • Reference Values
  • Serotonin / cerebrospinal fluid*
  • Tryptophan / cerebrospinal fluid

Substances

  • 3-hydroxykynurenine
  • Serotonin
  • Kynurenine
  • Hydroxyindoleacetic Acid
  • Tryptophan
  • 5-Hydroxytryptophan