Abstract
Radioadaptive response in cells from three patients was studied by induction of structural chromosome aberrations. Radioadaptive response was revealed in lymphocytes of all three patients. Coefficient of protection was 59.0% and did not differ from this after cell pretreatment with interferon. It is suggested the similarity or identity of mechanism of radioadaptive response and of interferon antimutagenic action which was implemented by non-repair way.
Publication types
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Comparative Study
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Nitroquinoline-1-oxide / pharmacology
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Adaptation, Physiological / drug effects
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Adaptation, Physiological / radiation effects*
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Cells, Cultured
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Chromosome Aberrations / genetics
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DNA Repair / drug effects
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Fast Neutrons
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Gamma Rays
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Humans
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Interferon-alpha / blood
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Interferon-alpha / radiation effects
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Lymphocytes / drug effects
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Lymphocytes / physiology
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Lymphocytes / radiation effects*
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Mutagens / pharmacology
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Schizophrenia / blood
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Schizophrenia / physiopathology*
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Tritium
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Ultraviolet Rays
Substances
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Interferon-alpha
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Mutagens
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Tritium
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4-Nitroquinoline-1-oxide