Refinements in the pathologic classification of non-Hodgkin lymphoma (NHL) have led to reevaluation of radiographic findings. Radiographs of 147 patients with NHL were reviewed, and bone destruction was found in 24. Patients with primitive or poorly differentiated tumors were more likely to have bone involvement than patients with well differentiated lymphomas. Permeative destruction was most common. There was no radiographic correlation between cortical bone destruction and disseminated marrow involvement. The relationship of conventional radiographs to technetium bone scans and gallium scans was assessed. Radiographic response to therapy was noted.