Incidence and severity of anaphylactoid reactions to colloid volume substitutes

Lancet. 1977 Feb 26;1(8009):466-9. doi: 10.1016/s0140-6736(77)91953-5.

Abstract

All available colloid volume substitutes carry the risk of anaphylactoid reactions. In a multicentre prospective trial, 69 cases of anaphylactoid reactions have been observed among 200 906 infusions of colloid volume substitutes. The frequency of severe reactions (shock, cardiac and/or respiratory arrest) was 0-003% for plasma-protein solutions, 0-006% for hydroxyethyl starch, 0-008% for dextran, and 0-038% for gelatin solutions.

Publication types

  • Clinical Trial

MeSH terms

  • Aged
  • Anaphylaxis / chemically induced
  • Anaphylaxis / epidemiology
  • Anaphylaxis / etiology*
  • Clinical Trials as Topic
  • Colloids / administration & dosage
  • Dextrans / adverse effects
  • Female
  • Gelatin / adverse effects
  • Humans
  • Infusions, Parenteral
  • Middle Aged
  • Plasma Substitutes / administration & dosage
  • Plasma Substitutes / adverse effects*
  • Prospective Studies
  • Serum Albumin / adverse effects
  • Starch / adverse effects

Substances

  • Colloids
  • Dextrans
  • Plasma Substitutes
  • Serum Albumin
  • Gelatin
  • Starch