An interspecies approach to the investigation of the red cell membrane glucose transporter

Biochim Biophys Acta. 1984 Mar 28;771(1):99-102. doi: 10.1016/0005-2736(84)90115-9.

Abstract

Glucose transport differs in red cells of various species. The following sequence of transport velocities was found: man greater than newborn pig greater than rat, dog greater than cattle greater than pig. No correlation was found between the amount of protein in band 3 and glucose transport activity. By contrast, a very clear peak in the band 4.5 region was found for newborn pigs, whereas adult pigs did not exhibit a corresponding peak in the electrophoresis. Thus further evidence is provided by our investigations in favour of band 4.5 region for glucose transport activity in red cells.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Animals, Newborn
  • Anion Exchange Protein 1, Erythrocyte / isolation & purification
  • Blood Glucose / metabolism*
  • Blood Proteins / isolation & purification
  • Carrier Proteins / blood*
  • Carrier Proteins / isolation & purification
  • Cattle
  • Dogs
  • Erythrocyte Membrane / metabolism*
  • Humans
  • Kinetics
  • Membrane Proteins / isolation & purification
  • Molecular Weight
  • Monosaccharide Transport Proteins
  • Nucleoside Transport Proteins
  • Rats
  • Species Specificity
  • Swine

Substances

  • Anion Exchange Protein 1, Erythrocyte
  • Blood Glucose
  • Blood Proteins
  • Carrier Proteins
  • Membrane Proteins
  • Monosaccharide Transport Proteins
  • Nucleoside Transport Proteins