Abstract
Foam cells in 4 human atherosclerotic plaques reacted with 3 rat monoclonal antibodies directed against T.200 ('anti-leucocyte common' antibody), HLA-Class II molecules and macrophage cytoplasm, respectively. Smooth muscle cells did not react. The results support the view that foam cells are monocyte-derived macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Animals
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Antibodies, Monoclonal / immunology
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Aorta / pathology*
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Arteriosclerosis / pathology*
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Coronary Vessels / pathology*
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Female
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Foam Cells / classification*
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Foam Cells / immunology
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Humans
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Immunoenzyme Techniques
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Macrophages / classification*
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Male
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Middle Aged
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Monocytes
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Rats