Alkylxanthines as adenosine receptor antagonists and membrane phosphodiesterase inhibitors in central nervous tissue: evaluation of structure-activity relationships

Life Sci. 1982 Dec 20;31(25):2857-67. doi: 10.1016/0024-3205(82)90676-2.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',3'-Cyclic-Nucleotide Phosphodiesterases / antagonists & inhibitors*
  • Adenosine / analogs & derivatives
  • Adenosine / metabolism
  • Animals
  • Brain / drug effects*
  • Cell Membrane / enzymology
  • In Vitro Techniques
  • Kinetics
  • Male
  • Nucleotidases / antagonists & inhibitors
  • Phosphodiesterase Inhibitors*
  • Phosphoric Diester Hydrolases
  • Rats
  • Receptors, Cell Surface / drug effects*
  • Receptors, Purinergic
  • Structure-Activity Relationship
  • Synaptosomes / metabolism
  • Xanthines / pharmacology*

Substances

  • Phosphodiesterase Inhibitors
  • Receptors, Cell Surface
  • Receptors, Purinergic
  • Xanthines
  • N(6)-cyclohexyladenosine
  • Nucleotidases
  • 2',3'-Cyclic-Nucleotide Phosphodiesterases
  • Phosphoric Diester Hydrolases
  • Adenosine