Synthesis and antitumor activity of cyclophosphamide analogues. 2. Preparation, hydrolytic studies, and anticancer screening of 5-bromocyclophosphamide, 3,5-dehydrocyclophosphamide, and related systems

J Med Chem. 1979 Feb;22(2):151-8. doi: 10.1021/jm00188a006.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / therapeutic use
  • Cyclophosphamide / analogs & derivatives*
  • Cyclophosphamide / chemical synthesis
  • Cyclophosphamide / pharmacology
  • Cyclophosphamide / therapeutic use
  • Drug Stability
  • Hydrolysis
  • In Vitro Techniques
  • Methods
  • Mice
  • Neoplasms, Experimental / drug therapy
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Cyclophosphamide