Abstract
The complex of 99Tc with the ligand 1,4,8,11-tetraazaundecane (2,3,2-tet) was prepared and was compared with the similar 99Tc complexes with ethylenediamine and 1,4,8,11-tetraazacyclotetradecane. The results are all consistent with the formula [TcO2(2,3,2-tet)]+. The biological behavior was tested with 99mTc in Wistar rats. A fast clearance via the kidneys was found, and no accumulation in any other organ was observed.
MeSH terms
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Animals
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Ethylenediamines
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Female
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Heterocyclic Compounds
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Heterocyclic Compounds, 1-Ring*
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Isotope Labeling / methods
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Organotechnetium Compounds*
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Polyamines*
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Rats
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Rats, Inbred Strains
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Technetium*
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Tissue Distribution
Substances
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Ethylenediamines
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Heterocyclic Compounds
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Heterocyclic Compounds, 1-Ring
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Organotechnetium Compounds
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Polyamines
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technetium Tc 99m 1,4,8,11-tetraazaundecane
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technetium Tc 99m cyclam
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technetium Tc 99m ethylenediamine
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Technetium