Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia

K Ishii; T Kita; N Kume; Y Nagano; C Kawai

doi:10.1016/0005-2760(88)90270-6

Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia

Biochim Biophys Acta. 1988 Oct 14;962(3):387-9. doi: 10.1016/0005-2760(88)90270-6.

Authors

K Ishii¹, T Kita, N Kume, Y Nagano, C Kawai

Affiliation

¹ Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.

PMID: 3167090
DOI: 10.1016/0005-2760(88)90270-6

Abstract

Acetylated low-density lipoprotein (acetyl-LDL) stimulated the incorporation of [14C]oleate into cholesteryl [14C]oleate in peritoneal macrophages from both normal and Watanabe heritable hyperlipidemic (WHHL) rabbits. A degradation study showed that macrophages from WHHL rabbits degraded the same amount of 125I-labeled acetyl-LDL as macrophages from normal rabbits. These findings indicate that macrophages of WHHL rabbits have functional acetyl-LDL receptors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Ascitic Fluid / cytology
Cell Adhesion Molecules*
Cells, Cultured
Cholesterol Esters / biosynthesis
Disease Models, Animal*
Hyperlipidemias / genetics*
Hyperlipidemias / metabolism
Hyperlipoproteinemia Type II*
Lipoproteins, LDL / metabolism*
Macrophages / metabolism*
Rabbits
Receptors, LDL / metabolism
Receptors, Scavenger

Substances

Cell Adhesion Molecules
Cholesterol Esters
Lipoproteins, LDL
Receptors, LDL
Receptors, Scavenger
acetyl-LDL
cholesteryl oleate