Synthesis and purification of 2-deoxy-2-[18F]fluoro-D-glucose and 2-deoxy-2-[18F]fluoro-D-mannose: characterization of products by 1H- and 19F-NMR spectroscopy

Int J Rad Appl Instrum A. 1986;37(8):695-701. doi: 10.1016/0883-2889(86)90263-7.

Abstract

A procedure has been developed that allows the separation of 2-deoxy-2-[18F]fluoro-D-glucose from 2-deoxy-2-[18F]fluoro-D-mannose employing selectively optimized ion-moderated partition chromatography. Both compounds can be obtained with a greater than 98% chemical and radiochemical purity in about one half-life of 18F. Both the alpha- and beta-anomers of both sugars were completely characterized by high-resolution 1H- and 19F-NMR spectroscopy. Various convenient preparation methods for 2-deoxy-2-[18F]fluoro-D-glucose were compared.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Deoxy Sugars / chemical synthesis*
  • Deoxyglucose / analogs & derivatives
  • Deoxyglucose / chemical synthesis*
  • Deoxyglucose / isolation & purification
  • Fluorine
  • Fluorodeoxyglucose F18
  • Magnetic Resonance Spectroscopy
  • Radioisotopes
  • Rhamnose / analogs & derivatives*
  • Rhamnose / chemical synthesis
  • Rhamnose / isolation & purification

Substances

  • Deoxy Sugars
  • Radioisotopes
  • Fluorodeoxyglucose F18
  • Fluorine
  • 2-deoxy-2-fluoromannose
  • Deoxyglucose
  • Rhamnose