Abstract
Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the beta-cells of the endocrine pancreas of transgenic mice. The alpha- and delta-cells normally found in the islets of Langerhans are rare and disordered. Well-vascularized beta-cell tumours arise in mice harbouring and inheriting these hybrid oncogenes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenoma, Islet Cell / genetics*
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Adenoma, Islet Cell / pathology
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Animals
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Antigens, Polyomavirus Transforming
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Antigens, Viral, Tumor / genetics*
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Cell Communication
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DNA, Recombinant
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Gene Expression Regulation
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Insulin / genetics*
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Mice
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Oncogenes*
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Pancreatic Neoplasms / genetics*
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Pancreatic Neoplasms / pathology
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Pedigree
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Phenotype
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Simian virus 40 / genetics
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Tissue Distribution
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Viral Proteins / genetics*
Substances
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Antigens, Polyomavirus Transforming
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Antigens, Viral, Tumor
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DNA, Recombinant
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Insulin
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Viral Proteins