Abstract
High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adsorption
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Chalcogens / chemical synthesis
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Chalcogens / metabolism*
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Coloring Agents / chemical synthesis
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Coloring Agents / metabolism*
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Gold / metabolism*
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Heterocyclic Compounds, 3-Ring / chemical synthesis
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Heterocyclic Compounds, 3-Ring / metabolism*
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Metal Nanoparticles*
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Spectrum Analysis, Raman / methods*
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Surface Properties
Substances
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Chalcogens
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Coloring Agents
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Heterocyclic Compounds, 3-Ring
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Gold