Acetate fuels the cancer engine

Costas A Lyssiotis; Lewis C Cantley

doi:10.1016/j.cell.2014.12.009

Acetate fuels the cancer engine

Cell. 2014 Dec 18;159(7):1492-4. doi: 10.1016/j.cell.2014.12.009.

Authors

Costas A Lyssiotis¹, Lewis C Cantley²

Affiliations

¹ Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA. Electronic address: col2007@med.cornell.edu.
² Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA. Electronic address: lcantley@med.cornell.edu.

PMID: 25525870
DOI: 10.1016/j.cell.2014.12.009

Abstract

Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and histone modification.

Publication types

Research Support, Non-U.S. Gov't