Abstract
Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bone Marrow / pathology
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Bone Marrow / physiopathology
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Cell-Derived Microparticles / physiology
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Cytokines / physiology
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Disease Progression
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Growth Substances / physiology
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Humans
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Models, Biological
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Neoplasm Metastasis / immunology
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Neoplasm Metastasis / pathology
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Neoplasm Metastasis / physiopathology*
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Neovascularization, Pathologic
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Spleen / pathology
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Spleen / physiopathology
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Systems Biology
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Tumor Microenvironment / immunology
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Tumor Microenvironment / physiology*
Substances
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Cytokines
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Growth Substances