Tumor heterogeneity confounds and illuminates: a case for Darwinian tumor evolution

Nat Med. 2014 Apr;20(4):344-6. doi: 10.1038/nm.3518.

Author

Kornelia Polyak¹

Affiliation

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

PMID: 24710378
DOI: 10.1038/nm.3518

No abstract available

MeSH terms

Breast Neoplasms / drug therapy
Breast Neoplasms / genetics*
Disease Progression
Drug Resistance, Neoplasm / genetics*
Epithelial-Mesenchymal Transition
Estrogen Receptor alpha / genetics*
Evolution, Molecular
Female
Genetic Heterogeneity*
Humans
Selection, Genetic*
Selective Estrogen Receptor Modulators / therapeutic use
Tamoxifen / therapeutic use

Substances

ESR1 protein, human
Estrogen Receptor alpha
Selective Estrogen Receptor Modulators
Tamoxifen