Abstract
Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR derivative (but not others) can indeed be used to follow the intracellular location of the model therapeutic drug in GFP cells.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Cell Line, Tumor
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Green Fluorescent Proteins / genetics
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Green Fluorescent Proteins / metabolism
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Humans
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Microscopy, Confocal
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Phthalazines / chemistry
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Piperazines / chemistry
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Rhodamines / chemistry*
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Silicon / chemistry*
Substances
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Phthalazines
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Piperazines
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Rhodamines
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Green Fluorescent Proteins
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olaparib
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Silicon