Abstract
The FDA recently approved an agonistic anti-CD30 drug conjugate, Brentuximab vedotin, for the treatment for CD30-positive lymphomas. The potent clinical activity of Brentuximab vedotin in Hodgkin's lymphoma and anaplastic large-cell lymphoma was greeted with great enthusiasm by oncologists as it provided a new treatment modality for these diseases. In this review, we will describe how we obtained the hybridoma by pursuing a basic research experiment unrelated to CD30. I will also review what we know about the normal biological functions of CD30 that were studied primarily in murine models of disease but also in patients. The picture emerging is that one of the primary functions of CD30 is the control of memory cells providing costimulation and trafficking information or inducing apoptosis in a microenvironment and cytokine milieu-dependent manner.
MeSH terms
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Animals
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Antibodies, Monoclonal / pharmacology
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Antibodies, Monoclonal / therapeutic use
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Brentuximab Vedotin
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CD30 Ligand / genetics
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CD30 Ligand / metabolism
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / metabolism
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CD8-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / metabolism
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Colitis / genetics
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Colitis / immunology
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Colitis / metabolism
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Cytotoxicity, Immunologic
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Disease Models, Animal
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Drug Screening Assays, Antitumor
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Gene Expression Regulation, Neoplastic
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Graft vs Host Disease / immunology
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Graft vs Host Disease / metabolism
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HLA Antigens / immunology
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Humans
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Immunoconjugates / pharmacology
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Immunoconjugates / therapeutic use
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Immunologic Memory
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Ki-1 Antigen / antagonists & inhibitors*
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Ki-1 Antigen / genetics
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Ki-1 Antigen / immunology
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Ki-1 Antigen / metabolism
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Mice
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Mice, Knockout
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Neoplasms / drug therapy
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Neoplasms / genetics
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Neoplasms / immunology
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Neoplasms / metabolism
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Research
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Signal Transduction
Substances
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Antibodies, Monoclonal
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Antineoplastic Agents
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CD30 Ligand
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HLA Antigens
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Immunoconjugates
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Ki-1 Antigen
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Brentuximab Vedotin