Breast cancer bone metastases: it's all about the neighborhood

Cell. 2013 Aug 29;154(5):957-959. doi: 10.1016/j.cell.2013.08.020.

Abstract

In order to establish themselves in distal sites, metastatic cancer cells need to acquire organ-specific traits. Zhang et al. provide evidence in breast cancer that a tumor cell's acquisition of properties for successful bone metastasis is influenced by signals from the stroma of the primary tumor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Bone Neoplasms / secondary*
  • Breast Neoplasms / pathology*
  • Humans
  • Neoplasm Metastasis*
  • Signal Transduction*