Qualitative and quantitative changes in saliva among patients with thyroid dysfunction prior to and following the treatment of the dysfunction

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 May;115(5):617-23. doi: 10.1016/j.oooo.2012.12.009. Epub 2013 Feb 28.

Abstract

Objective: Animal studies have shown thyroid dysfunction affects salivary gland functioning, however conclusive human studies are lacking. We sought to assess the qualitative and quantitative changes in saliva among subjects with thyroid dysfunction prior to and following treatment.

Material and methods: A longitudinal observational study of 153 newly diagnosed subjects who had hypothyroidism (n = 107) or hyperthyroidism (n = 46), aged 18-45 years, fulfilling the inclusion/exclusion criteria was conducted. Analysis of salivary parameters (stimulated salivary flow rate (SSFR), pH and buffering capacity) was performed at diagnosis (baseline), on attaining euthyroid state and 3 months thereafter.

Results: Subjects were 86% females, and at baseline 13% of subjects had hyposalivation. Mean SSFR, pH, buffering capacity as well as percentage of hypothyroid subjects having normal salivation increased following thyroid treatment.

Conclusions: Thyroid dysfunction affects salivary gland function. Subjects with chronic hyposalivation should have thyroid function assessment if the known established causes are excluded.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies / blood
  • Antithyroid Agents / therapeutic use
  • Autoantigens / immunology
  • Buffers
  • Carbimazole / therapeutic use
  • Female
  • Follow-Up Studies
  • Humans
  • Hydrogen-Ion Concentration
  • Hyperthyroidism / blood
  • Hyperthyroidism / drug therapy
  • Hyperthyroidism / physiopathology*
  • Hypothyroidism / blood
  • Hypothyroidism / drug therapy
  • Hypothyroidism / physiopathology*
  • Immunoglobulins, Thyroid-Stimulating / blood
  • Iodide Peroxidase / immunology
  • Iron-Binding Proteins / immunology
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Receptors, Thyrotropin / blood
  • Saliva / metabolism
  • Saliva / physiology*
  • Salivary Glands / metabolism
  • Salivary Glands / physiopathology
  • Secretory Rate / physiology
  • Thyroglobulin / immunology
  • Thyronines / blood
  • Thyrotropin / blood
  • Thyroxine / therapeutic use
  • Triiodothyronine / blood
  • Xerostomia / blood
  • Xerostomia / etiology
  • Xerostomia / physiopathology
  • Young Adult

Substances

  • Antibodies
  • Antithyroid Agents
  • Autoantigens
  • Buffers
  • Immunoglobulins, Thyroid-Stimulating
  • Iron-Binding Proteins
  • Receptors, Thyrotropin
  • Thyronines
  • thyrotropin-binding inhibitory immunoglobulin
  • Triiodothyronine
  • Carbimazole
  • Thyrotropin
  • Thyroglobulin
  • TPO protein, human
  • Iodide Peroxidase
  • Thyroxine