Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807

J Alzheimers Dis. 2013;34(2):457-68. doi: 10.3233/JAD-122059.

Abstract

Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here in, we describe the first human brain images with [F-18]-T807.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnostic imaging*
  • Alzheimer Disease / metabolism
  • Carbolines* / metabolism
  • Early Diagnosis
  • Female
  • Fluorine Radioisotopes* / metabolism
  • Frontal Lobe / diagnostic imaging
  • Frontal Lobe / metabolism
  • Humans
  • Male
  • Middle Aged
  • Phosphorylation / physiology
  • Positron-Emission Tomography / methods*
  • tau Proteins* / metabolism

Substances

  • Carbolines
  • Fluorine Radioisotopes
  • MAPT protein, human
  • tau Proteins
  • 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole