Abstract
(44)Ti/(44)Sc radionuclide generators are of interest for molecular imaging. The 3.97 hours half-life of (44)Sc and its high positron branching of 94.27% may stimulate the application of (44)Sc-labeled PET radiopharmaceuticals. This review describes the current status of (44)Ti production, (44)Ti/(44)Sc radionuclide generator development, post-processing of generator eluates towards medical application, identification of ligands adequate to Sc(III) co-ordination chemistry, proof-of-principle labeling of (44)Sc-DOTA-octreotides, investigation of in vitro and in vivo parameters, and initial applications for molecular imaging - both in small animals and humans.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adsorption
-
Animals
-
Cation Exchange Resins
-
Chelating Agents / chemical synthesis
-
Drug Stability
-
Half-Life
-
Heterocyclic Compounds, 1-Ring / chemical synthesis
-
Humans
-
Liver Neoplasms / diagnostic imaging
-
Mice
-
Mice, Nude
-
Neoplasms, Experimental / diagnostic imaging
-
Nickel
-
Nuclear Reactors
-
Positron-Emission Tomography*
-
Puromycin / chemical synthesis
-
Radioisotopes / isolation & purification*
-
Radioisotopes / pharmacokinetics
-
Radionuclide Generators*
-
Radiopharmaceuticals / chemical synthesis*
-
Radiopharmaceuticals / pharmacokinetics
-
Scandium / isolation & purification*
-
Scandium / pharmacokinetics
-
Titanium / isolation & purification*
-
Transplantation, Heterologous
Substances
-
Cation Exchange Resins
-
Chelating Agents
-
Heterocyclic Compounds, 1-Ring
-
Radioisotopes
-
Radiopharmaceuticals
-
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
-
Puromycin
-
Nickel
-
Titanium
-
Scandium