High beam current operation of a PETtrace™ cyclotron for 18F- production

S Eberl; T Eriksson; O Svedberg; J Norling; D Henderson; P Lam; M Fulham

doi:10.1016/j.apradiso.2012.03.007

High beam current operation of a PETtrace™ cyclotron for 18F- production

Appl Radiat Isot. 2012 Jun;70(6):922-30. doi: 10.1016/j.apradiso.2012.03.007. Epub 2012 Mar 18.

Authors

S Eberl¹, T Eriksson, O Svedberg, J Norling, D Henderson, P Lam, M Fulham

Affiliation

¹ Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. eberl@staff.usyd.edu.au

PMID: 22476015
DOI: 10.1016/j.apradiso.2012.03.007

Abstract

Upgrades and optimisation achieved 160 μA total target current operation of a GE PETtrace cyclotron in dual target mode for the routine production of [(18)F]FDG for >2 years. Approximately 900 GBq of (18)F(-) and >500 GBq of [(18)F]FDG can be produced routinely in a single production run, meeting the routine [(18)F]FDG requirements with our customer base and achieving economies of scale. Production of >1 TBq of (18)F(-) in a single run was achieved. Reliability, saturation and synthesis yields were not adversely affected.

MeSH terms

Cyclotrons*
Equipment Design
Equipment Failure Analysis
Fluorodeoxyglucose F18 / chemical synthesis*
Fluorodeoxyglucose F18 / radiation effects
Isotope Labeling / instrumentation*
Materials Testing
Positron-Emission Tomography / instrumentation*
Radiation Dosage
Radiopharmaceuticals / chemical synthesis*

Substances

Radiopharmaceuticals
Fluorodeoxyglucose F18