[(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX

Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3354-7. doi: 10.1002/anie.201107333. Epub 2012 Feb 17.

Abstract

Enhanced receptor selectivity: carbonic anhydrase inhibitors are relevant for both cancer diagnosis and therapy. Combining non-radioactive Re compounds with their radioactive (99m)Tc homologs enables the use of identical molecules for therapy and imaging (theragnostic). The syntheses and in vitro evaluation of [(Cp-R)M(CO)(3)] (Cp=cyclopentadienyl, M=Re, (99m)Tc) with R being a highly potent carbonic-anhydrase-targeting vector is reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Neoplasm / chemistry*
  • Antigens, Neoplasm / metabolism
  • Carbonic Anhydrase IX
  • Carbonic Anhydrase Inhibitors / chemistry*
  • Carbonic Anhydrase Inhibitors / pharmacology
  • Carbonic Anhydrases / chemistry*
  • Carbonic Anhydrases / metabolism
  • Cell Proliferation / drug effects
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology
  • HEK293 Cells
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Organotechnetium Compounds / chemistry
  • Rhenium / chemistry
  • Sulfonamides / chemistry*
  • Sulfonic Acids / chemistry*
  • Tamoxifen / chemistry

Substances

  • Antigens, Neoplasm
  • Carbonic Anhydrase Inhibitors
  • Coordination Complexes
  • Organotechnetium Compounds
  • Sulfonamides
  • Sulfonic Acids
  • Tamoxifen
  • Rhenium
  • sulfamic acid
  • CA9 protein, human
  • Carbonic Anhydrase IX
  • Carbonic Anhydrases