Abstract
The orthotopic model reproduces aspects of the tumour microenvironment and emulates a number of important biological features of cancer progression, angiogenesis, metastasis and resistance. Due to its parallels with human cancer, the model can be used to evaluate therapeutic responses to various therapies. This review outlines the importance of using the orthotopic implantation of tumour cells in mice models for evaluating the effectiveness of antivascular therapies.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
-
Validation Study
MeSH terms
-
Angiogenesis Inhibitors / administration & dosage
-
Angiogenesis Inhibitors / therapeutic use*
-
Animals
-
Antineoplastic Agents / administration & dosage
-
Disease Models, Animal
-
Humans
-
Mice
-
Neoplasm Transplantation / methods
-
Neoplasms, Experimental / blood supply*
-
Neoplasms, Experimental / drug therapy*
-
Neovascularization, Pathologic / therapy
-
Tumor Microenvironment
-
Xenograft Model Antitumor Assays
Substances
-
Angiogenesis Inhibitors
-
Antineoplastic Agents