Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the Tracerlab FXFN and Tracerlab MXFDG module for imaging the peripheral benzodiazepine receptor with PET

Thomas Bourdier; Tien Q Pham; David Henderson; Timothy Jackson; Peter Lam; Michael Izard; Andrew Katsifis

doi:10.1016/j.apradiso.2011.07.014

Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the Tracerlab FXFN and Tracerlab MXFDG module for imaging the peripheral benzodiazepine receptor with PET

Appl Radiat Isot. 2012 Jan;70(1):176-83. doi: 10.1016/j.apradiso.2011.07.014. Epub 2011 Aug 5.

Authors

Thomas Bourdier¹, Tien Q Pham, David Henderson, Timothy Jackson, Peter Lam, Michael Izard, Andrew Katsifis

Affiliation

¹ PET and Nuclear Medicine Department, Royal Prince Alfred Hospital, Missenden road, Camperdown NSW 2050, Sydney, Australia. thomas@nucmed.rpa.cs.nsw.gov.au

PMID: 21852142
DOI: 10.1016/j.apradiso.2011.07.014

Abstract

[(18)F]PBR111 and [(18)F]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [(18)F]PBR111 and [(18)F]PBR102 in the Tracerlab FX(FN) (30±2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MX(FDG) (25±2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was >99% and specific activity was >150GBq/μmol after less than 60min of preparation time.

MeSH terms

Contrast Media / chemical synthesis*
Equipment Design
Fluorine Radioisotopes / chemistry*
Humans
Isotope Labeling / instrumentation*
Positron-Emission Tomography / methods*
Protein Binding
Receptors, GABA / chemistry*
Robotics / instrumentation*

Substances

Contrast Media
Fluorine Radioisotopes
Receptors, GABA
TSPO protein, human