Abstract
The use of fluorescent (or luminescent) and metal contrast agents in high-throughput screens, in vitro assays, and molecular imaging procedures has rapidly expanded in recent years. Here we describe the development and utility of high-affinity ligands for cancer theranostics and other in vitro screening -studies. In this context, we also illustrate the syntheses and use of heteromultivalent ligands as targeted imaging agents.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Binding Sites
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Cell Line
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Chelating Agents / chemical synthesis
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Chelating Agents / chemistry*
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Chelating Agents / metabolism
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / metabolism
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Heterocyclic Compounds, 1-Ring / chemical synthesis
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Heterocyclic Compounds, 1-Ring / chemistry
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Heterocyclic Compounds, 1-Ring / metabolism
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Humans
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Lanthanoid Series Elements / chemical synthesis
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Lanthanoid Series Elements / chemistry*
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Lanthanoid Series Elements / metabolism
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Ligands
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Magnetic Resonance Imaging / methods
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Mice
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Microscopy, Fluorescence / methods
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Molecular Imaging / methods*
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Neoplasms / diagnosis*
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Neoplasms / drug therapy
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Pentetic Acid / chemical synthesis
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Pentetic Acid / chemistry
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Pentetic Acid / metabolism
Substances
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Chelating Agents
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Fluorescent Dyes
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Heterocyclic Compounds, 1-Ring
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Lanthanoid Series Elements
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Ligands
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1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
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Pentetic Acid