Automated production of [11C]acetate and [11C]palmitate using a modified GE Tracerlab FX(C-Pro)

Appl Radiat Isot. 2011 Apr;69(4):691-8. doi: 10.1016/j.apradiso.2011.01.002. Epub 2011 Jan 8.

Abstract

As researchers explore new applications for positron emission tomography radiopharmaceuticals, the demand for effective and readily available radiopharmaceuticals continues to increase. The syntheses of two such radiopharmaceuticals, [(11)C]acetate and [(11)C]palmitate, can be automated on the GE Tracerlab FX(C-Pro) by utilizing Grignard reactions. Radiochemical purities of the [(11)C]acetate and the [(11)C]palmitate products were high (>98% and >99.9%, respectively) with average non-corrected yields of 18% (n = 3) and 10% (n = 5), respectively. These data comprise the validation trials for site qualification of clinical production of both radiopharmaceuticals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acetic Acid / chemical synthesis*
  • Automation*
  • Carbon Radioisotopes / chemistry*
  • Palmitic Acid / chemical synthesis*
  • Positron-Emission Tomography

Substances

  • Carbon Radioisotopes
  • Palmitic Acid
  • Acetic Acid