Abstract
MALDI Imaging Mass Spectrometry is a molecular analytical technology capable of simultaneously measuring multiple analytes directly from intact tissue sections. Histological features within the sample can be correlated with molecular species without the need for target-specific reagents such as antibodies. Several studies have demonstrated the strength of the technology for uncovering new markers that correlate with disease severity as well as prognosis and therapeutic response. This review describes technological aspects of imaging mass spectrometry together with applications in cancer research.
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Diagnostic Imaging / instrumentation
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Diagnostic Imaging / methods*
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Humans
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Lipids / analysis
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Molecular Diagnostic Techniques / instrumentation
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Molecular Diagnostic Techniques / methods*
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Neoplasm Proteins / analysis
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Neoplasms* / diagnosis
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Neoplasms* / metabolism
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Neoplasms* / pathology
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Peptides / analysis
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Pharmaceutical Preparations / analysis
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
Substances
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Lipids
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Neoplasm Proteins
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Peptides
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Pharmaceutical Preparations