Abstract
In search of a serotonin 5-HT(7) radiotracer for positron emission tomography, we developed 1-[2-[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl 4-fluorobenzoate. After labeling in good yield with fluorine-18 via nitro for fluorine exchange, preliminary biological experiments with autoradiographies failed to evidence any specific 5-HT(7) receptor delineation.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Autoradiography
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Benzoates / chemistry
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Benzoates / pharmacokinetics*
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Brain / metabolism
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Fluorine Radioisotopes*
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Hydrophobic and Hydrophilic Interactions
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Isotope Labeling
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Positron-Emission Tomography / methods*
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Radiopharmaceuticals / chemistry
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Radiopharmaceuticals / pharmacokinetics
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Rats
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Receptors, Serotonin / analysis*
Substances
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Benzoates
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Fluorine Radioisotopes
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Radiopharmaceuticals
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Receptors, Serotonin
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serotonin 7 receptor
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4-fluorobenzoic acid