Looking for a 5-HT7 radiotracer for positron emission tomography

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3730-3. doi: 10.1016/j.bmcl.2010.04.076. Epub 2010 Apr 24.

Abstract

In search of a serotonin 5-HT(7) radiotracer for positron emission tomography, we developed 1-[2-[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl 4-fluorobenzoate. After labeling in good yield with fluorine-18 via nitro for fluorine exchange, preliminary biological experiments with autoradiographies failed to evidence any specific 5-HT(7) receptor delineation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoradiography
  • Benzoates / chemistry
  • Benzoates / pharmacokinetics*
  • Brain / metabolism
  • Fluorine Radioisotopes*
  • Hydrophobic and Hydrophilic Interactions
  • Isotope Labeling
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / pharmacokinetics
  • Rats
  • Receptors, Serotonin / analysis*

Substances

  • Benzoates
  • Fluorine Radioisotopes
  • Radiopharmaceuticals
  • Receptors, Serotonin
  • serotonin 7 receptor
  • 4-fluorobenzoic acid