FDG uptake in axillary lymph nodes after vaccination against pandemic (H1N1)

Eur Radiol. 2010 May;20(5):1251-3. doi: 10.1007/s00330-010-1719-5. Epub 2010 Feb 26.

Abstract

Objective: To alert the imaging community to potential false positive findings related to current immunization programmes against H1N1 influenza virus.

Methods: We reviewed 10 patients referred for positron emission tomography/computed tomography (PET/CT) who had undergone recent vaccination.

Results: All studies showed( 18)F-fluorodeoxyglucose (FDG) uptake in the draining axillary lymph nodes close to the vaccination site, while low-dose CT revealed lymph nodes ranged between 0.5 cm and 1.2 cm at the same site.

Conclusion: This potential pitfall in PET/CT should be borne in mind during current vaccination programmes.

MeSH terms

  • Adult
  • Aged
  • Axilla
  • Disease Outbreaks
  • False Positive Reactions
  • Female
  • Fluorodeoxyglucose F18 / pharmacokinetics*
  • Greece / epidemiology
  • Humans
  • Influenza A Virus, H1N1 Subtype*
  • Influenza Vaccines*
  • Influenza, Human / epidemiology
  • Influenza, Human / prevention & control
  • Lymph Nodes / diagnostic imaging*
  • Lymphatic Metastasis / diagnostic imaging*
  • Male
  • Mediastinum
  • Middle Aged
  • Neoplasms / pathology*
  • Positron-Emission Tomography*
  • Radiopharmaceuticals / pharmacokinetics*
  • Tomography, X-Ray Computed*

Substances

  • Influenza Vaccines
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18