Abstract
Fully automated synthesis and initial PET evaluation of a TSPO radioligand, [11C]PBR28 (N-(2-[11C]methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide), are reported. These results facilitate the potential preclinical and clinical PET studies of [11C]PBR28 in animals and humans.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Carbon Radioisotopes
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Carrier Proteins / antagonists & inhibitors*
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Carrier Proteins / metabolism
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Female
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GABA-A Receptor Antagonists*
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Ligands
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Positron-Emission Tomography*
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Pyrimidines / chemical synthesis*
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Pyrimidines / chemistry
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Radiopharmaceuticals / chemical synthesis*
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Radiopharmaceuticals / chemistry
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Rats
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Rats, Sprague-Dawley
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Receptors, GABA-A / metabolism
Substances
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(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine
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Carbon Radioisotopes
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Carrier Proteins
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GABA-A Receptor Antagonists
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Ligands
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Pyrimidines
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Radiopharmaceuticals
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Receptors, GABA-A
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Tspo protein, rat