Catalytic synthesis of amino acid and peptide derivatized gadonanotubes

J Am Chem Soc. 2009 Jun 24;131(24):8342-3. doi: 10.1021/ja900918x.

Abstract

A new Rh(6)(CO)(16)-catalyzed functionalization of gadonanotube MRI probes offers the opportunity to prepare a number of amino acid and peptide derivatized gadonanotubes under RT conditions, containing, for example, the cyclic RGD peptide for the biological targeting of cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acids / chemical synthesis*
  • Amino Acids / chemistry
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry
  • Catalysis
  • Gadolinium / chemistry*
  • Magnetic Resonance Imaging
  • Nanotubes, Peptide / chemistry*
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry*
  • Organometallic Compounds
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry
  • Rhodium / chemistry

Substances

  • Amino Acids
  • Biocompatible Materials
  • Nanotubes, Peptide
  • Oligopeptides
  • Organometallic Compounds
  • Peptides, Cyclic
  • arginyl-glycyl-aspartic acid
  • Gadolinium
  • Rhodium