Calculation of the biological effective dose for piecewise defined dose-rate fits

Med Phys. 2009 Mar;36(3):904-7. doi: 10.1118/1.3070587.

Abstract

An algorithmic solution to the biological effective dose (BED) calculation from the Lea-Catcheside formula for a piecewise defined function is presented. Data from patients treated for metastatic thyroid cancer were used to illustrate the solution. The Lea-Catcheside formula for the G-factor of the BED is integrated numerically using a large number of small trapezoidal fits to each integral. The algorithmically calculated BED is compatible with an analytic calculation for a similarly valued exponentially fitted dose-rate plot and is the only resolution for piecewise defined dose-rate functions.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Biophysical Phenomena
  • Humans
  • Iodine Radioisotopes
  • Positron-Emission Tomography / statistics & numerical data
  • Radiometry / statistics & numerical data*
  • Radiotherapy Planning, Computer-Assisted / statistics & numerical data
  • Salivary Glands / diagnostic imaging
  • Thyroid Neoplasms / radiotherapy
  • Thyroid Neoplasms / secondary

Substances

  • Iodine Radioisotopes