Abstract
Emerging data that show immune-regulating molecules may be ectopically expressed on human tumors suggest that novel mechanisms may induce tumor-related immune suppression, and support the use of antibodies and small molecules to target those immune-suppressive moities.
MeSH terms
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Animals
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Antigens, CD / metabolism*
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CTLA-4 Antigen
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Humans
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Immune System
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Lymphocyte Activation
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Melanoma / immunology
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Melanoma / metabolism*
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Mice
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Neoplasm Invasiveness
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Phenotype
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Signal Transduction
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Skin Neoplasms / immunology
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Skin Neoplasms / metabolism*
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Wnt Proteins / metabolism
Substances
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Antigens, CD
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CTLA-4 Antigen
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CTLA4 protein, human
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Ctla4 protein, mouse
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Wnt Proteins