PET imaging with 11C-acetate in prostate cancer: a biochemical, radiochemical and clinical perspective

Eur J Nucl Med Mol Imaging. 2008 May;35(5):942-9. doi: 10.1007/s00259-007-0662-4.

Abstract

Purpose: In the present study, the potential clinical role of 11C-acetate PET mainly in the differential diagnosis, in the staging and in the follow-up of prostate cancer patients is reported.

Methods: Each of the above points has been accurately investigated by studying the specific biochemical and radiobiochemical behaviour of this positron emitter compound.

Results and conclusion: The imaging quality of 11C-acetate PET and its unique mechanisms of cellular uptake, make such radiotracer a powerful tool in evaluating all the steps of the prostatic cancer.

MeSH terms

  • Acetates*
  • Carbon*
  • Diagnosis, Differential
  • Humans
  • Male
  • Neoplasm Staging
  • Positron-Emission Tomography / methods*
  • Prostatic Neoplasms / diagnosis*
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Acetates
  • Radiopharmaceuticals
  • carbon-11 acetate
  • Carbon