Imaging and dosimetry of 99mTc EC annexin V: preliminary clinical study targeting apoptosis in breast tumors

Appl Radiat Isot. 2008 Sep;66(9):1175-82. doi: 10.1016/j.apradiso.2008.01.012. Epub 2008 Jan 26.

Abstract

Background: Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use (99m)Tc EC-annexin V to image tumor cells undergoing apoptosis.

Methods: In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering (99m)Tc EC-annexin V.

Results: Nine of the 10 cases showed detectable (99m)Tc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment.

Conclusions: Apoptosis can be quantified using (99m)Tc EC-annexin V.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Annexin A5* / chemical synthesis
  • Apoptosis* / drug effects
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / pathology
  • Female
  • Humans
  • Middle Aged
  • Organotechnetium Compounds* / chemical synthesis
  • Prospective Studies
  • Radiometry
  • Radiopharmaceuticals / chemical synthesis
  • Tomography, Emission-Computed, Single-Photon / methods

Substances

  • Annexin A5
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium Tc 99m ethylenedicysteine annexin V