Symmetric atlasing and model based segmentation: an application to the hippocampus in older adults

Med Image Comput Comput Assist Interv. 2006;9(Pt 2):58-66. doi: 10.1007/11866763_8.

Abstract

In model-based segmentation, automated region identification is achieved via registration of novel data to a pre-determined model. The desired structure is typically generated via manual tracing within this model. When model-based segmentation is applied to human cortical data, problems arise if left-right comparisons are desired. The asymmetry of the human cortex requires that both left and right models of a structure be composed in order to effectively segment the desired structures. Paradoxically, defining a model in both hemi-spheres carries a likelihood of introducing bias to one of the structures. This paper describes a novel technique for creating a symmetric average model in which both hemispheres are equally represented and thus left-right comparison is possible. This work is an extension of that proposed by Guimond et al. Hippocampal segmentation is used as a test-case in a cohort of 118 normal eld-erly subjects and results are compared with expert manual tracing.

Publication types

  • Evaluation Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Algorithms*
  • Anatomy, Artistic / methods
  • Artificial Intelligence*
  • Computer Simulation
  • Hippocampus / anatomy & histology*
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Medical Illustration
  • Middle Aged
  • Models, Neurological
  • Pattern Recognition, Automated / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity