Abstract
We fabricated a microfluidic DNA synthesizer out of perfluoropolyether (PFPE), an elastomer with excellent chemical compatibility which makes it possible to perform organic chemical reactions, and synthesized 20-mer oligonucleotides on chip.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Chromatography, High Pressure Liquid
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DNA / chemical synthesis*
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Elastomers / chemistry
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Ethers / chemistry
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Fluorocarbons / chemistry
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Microfluidic Analytical Techniques / instrumentation*
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Microfluidic Analytical Techniques / methods
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Oligonucleotides / chemistry*
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Solvents / chemistry*
Substances
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Elastomers
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Ethers
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Fluorocarbons
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Oligonucleotides
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Solvents
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perfluoropolyether
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DNA