Abstract
Aromatase is a particularly good target in the treatment of estrogen receptor positive breast cancer. Novel carbon-11 labeled sulfonanilide analogues, N-[11C]methyl-N-(2-alkyloxy-4-nitrophenyl)-methanesulfonamides ([11C]3a-f, alkyl=propyl, isopropyl, 1-ethyl-propyl, cyclopentyl, cyclohexyl, and cyclohexylethyl), were designed and synthesized as potential PET agents for imaging of aromatase in breast cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anilides / chemical synthesis*
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Aromatase Inhibitors / chemical synthesis*
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Breast Neoplasms / diagnostic imaging*
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Breast Neoplasms / enzymology*
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Carbon Radioisotopes
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Cell Line, Tumor
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Cyclooxygenase 2 Inhibitors / pharmacology
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Drug Design
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Female
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Humans
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Indicators and Reagents
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Isotope Labeling
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Nitrobenzenes / pharmacology
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Positron-Emission Tomography / methods*
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Radiopharmaceuticals / chemical synthesis*
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Sulfonamides / pharmacology
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Tetrazolium Salts
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Thiazoles
Substances
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Anilides
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Aromatase Inhibitors
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Carbon Radioisotopes
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Cyclooxygenase 2 Inhibitors
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Indicators and Reagents
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Nitrobenzenes
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Radiopharmaceuticals
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Sulfonamides
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Tetrazolium Salts
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Thiazoles
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N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
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thiazolyl blue