Intensity-modulated radiation therapy is a delivery system that, when coupled with a treatment-planning optimization system, presents the opportunity to conform the dose to the target better than 3-dimensional conformal therapy, particularly in the case of concave targets. Appropriate clinical applications of this technology to challenging patient treatment scenarios requires careful consideration of issues related to target volume-dose heterogeneity and the influence of patient setup uncertainties. These issues are reviewed and illustrated. To date, clinical reports of these treatments for prostate and head and neck cancers have the most mature data. Those results are summarized here. Future applications of this technology can be expected to take careful, considered advantage of this technology to further rearrange dose distributions across target volumes to produce an integrated overall gain in treatment objectives. However, these innovative applications need to be approached with caution, preferably in prospective clinical trials that would help determine if the hypothetical clinical benefits are in fact realizable.